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[서론] Diclofenac : 1960년대 개발된 phenylacetic acid계 비스테로이드성 항염증 약물(NSAID)로, 프로스타글란딘의 합성을 강력하게 억제하는 물질. 치료영역 : 류마티스성 관절염, 골관절염, 강직성 척추염 및 급성 통풍성 관절염, 수술 후 통증 완화, 월경통 및 여러 가지 안증상 부작용 : Diclofenac 경구제제는 다른 NSAID 들과 마찬가지로 위장관 부작용이 흔하게 발생하며, 신기능 장애 및 과민성 반응 등은 이 약물의 우수한 치료효과에도 불구하고 이의 장기간 전신 투여를 제한하는 요인이 되고 있음. 경피흡수제 개발사유 : 경구투여에 따른 전신 부작용을 최소화할 수 있을 것으로 기대되는 NSAID제, 특히 우수한 약효가 입증된 기존의 경구용 소염 진통제를 이용하여 해당 병소 부위에만 약물을 전달함으로써 치료효과를 극대화하고 전신부작용을 최소화하고자 하는 경피 흡수제의 개발이 두드러짐. 본 연구 수행 목적 : 한국인에서 diclfenac 플라스터(류마스탑®)를 반복적으로 국소 부착 후 체내 전신순환으로의 흡수에 따른 diclofenac의 약동학적 특성을 분석하였음.
[연구대상 및 방법] 1. 연구대상 정상 성인남자 16명 (이들 중 2명은 각각 연구계획서 위배 및 약물농도 분석 과정에서 diclofenac의 peak와 겹치는 미상의 물질이 검출되어 본 연구결과 분석에서 제외) 본 연구 참여자의 약물대사능의 동질성을 확보하기 위해 diclofenac의 대사에 관여하는 CYP2C9의 유전형을 Nasu 등이 시행한 PCR 방법을 변형하여 분석하였으며, 피험자 모두 이 효소의 유전적 결함이 없는 wild type으로 판명되었음.
2. 연구방법 약물투여 및 시료채취 : 류마스탑 플라스터 및 위약 플라스터 제공 (녹십자), 자세한 방법 노문 참조 플라스터, 혈장 및 요내 diclofenac 농도의 측정 : 논문 참조
3. 약동학적 분석 : 논문 참조 [결과] 14명의 피험자에서 24시간 동안 경피흡수된 diclofenac 용량 : 평균 6.60 ± 3.48 mg (전체 플라스터내 총 diclofenac 함유량 (95.17 ± 0.71 mg)의 6.9 ± 3.5%에 해당하는 양) 항정상태 도달 시간 : 플라스터를 7일 간 반복하여 경피투여시 거의 항정상태에 도달하였으며, 반복투여 후 4일 째에 항정상태 약물농도의 약 86%에 도달. (14일 동안 매 24시간 간격으로 반복 투여) 1회 부착 후 Cmax : 7.4 ± 3.6 ng/ml 1회 부착 후 Tmax : 13.2 ± 9.4 ng/ml 14일 부착 후 항정상태 혈장 최고 농도 : 15.6 ± 11.3 ng/ml 최고 농도에 이르는 시간 Tmax : 7.9 ± 7.4 시간 매 24시간 간격으로 diclofenac DEA 플라스터를 반복 부착 후 각 개인에서의 혈장농도 데이터는 2-compartment, 2-segment simultaneous input model에 의해 잘 설명되어졌음.
[고안] Diclofenac의 경피를 통한 흡수량은 전체 플라스터내 함유량(95.17mg)의 약 6.9 % ⇒ 185 mg의 diclofenac hydroxyethyl pyrrolidine (DHEP)를 12시간 간격으로 15회 반복 경피 투여 후의 흡수율 5%를 약간 상회하는 결과, DHEP gel 제형을 국소 도포에 따른 6-7% 흡수율과는 비슷한 결과 ![](data:image/png;base64,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)
각 피험자에서의 항정상태 혈장 최고 농도(Cmax)와 13일 간의 평균 diclofenac 흡수량과의 상관계수가 r=0.520 으로 개체간 혈장 약물 농도가 흡수량에 의해 영향을 받는 것으로 나타남.
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